Medication · antispasmodic gi

Supplements and Hyoscine butylbromide.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Hyoscine butylbromide, sold under the brand names Buscopan, Buscopan Cramps, is a gastrointestinal antispasmodic: it relaxes smooth muscle in the gut wall.

Hyoscine butylbromide is a gastrointestinal antispasmodic. It is prescribed for irritable bowel syndrome and similar functional gut conditions. The class includes mebeverine, hyoscine, alverine, and peppermint oil. Mechanism varies. Anticholinergic (hyoscine). Direct smooth muscle relaxation (mebeverine). Or calcium channel modulation (peppermint oil). The supplement surface is small because the agents have minimal CYP metabolism. Anticholinergic burden matters most when antispasmodics like hyoscine are combined with other anticholinergic medicines or supplements. Older patients are most sensitive. Peppermint oil enteric-coated capsules count as a supplement in their own right, and have a modest evidence base for IBS symptom relief; Cochrane reviews place the effect size as small but real. Anyone combining a prescribed antispasmodic with peppermint oil should ideally do so on advice rather than randomly.

We have not yet completed an explicit assessment of supplement interactions with Hyoscine butylbromide in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Hyoscine butylbromide alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

Loading database stats…

For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

Type the supplement name. Click each match to add it.

Your medications

Brand or generic name works. Click each match to add it.

Anything we should know? (optional)

Pick any that apply. We adjust the findings where context changes the answer.

I confirm I am 18 or over. This tool gives evidence-graded information, not medical advice; always discuss changes with your GP or pharmacist.

Add at least one supplement and one medication to check.

Not sure where to start? Try one:

How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

Want this reasoning across everything you take?

This page checks the pairs you enter. A personalised Distil report applies the same graded, cited reasoning to your whole stack: your goals, conditions, medications, diet, and the compounds worth adding or dropping. The interactions check is one section of it. You can read a real one in full before you decide.

See a real sample report

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.