Supplements and Glyceryl trinitrate.
Glyceryl trinitrate, sold under the brand names Glytrin Spray, Coro-Nitro Pump Spray, Transiderm-Nitro, Trintek, Suscard, is classified under "nitrate" in the BNF.
Glyceryl trinitrate (brand names Glytrin Spray, Coro-Nitro Pump Spray, Transiderm-Nitro, Trintek, Suscard) sits at NHSBSA prescribing rank 119 in the 2024/25 PCA statistics. The BNF classifies it under "nitrate". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Glyceryl trinitrate with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.
Below are the 3 documented pairs we have explicitly assessed against Glyceryl trinitrate in the Distil database: 3 amber. The pairs cluster around 1 mechanism: Additive vasodilation. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive vasodilation
Amber Does Beetroot Extract interact with ?
Taking beetroot with glyceryl trinitrate (GTN) can add up their blood-pressure-lowering effects, so you may notice more dizziness, lightheadedness or a headache, particularly when a GTN spray or patch is working, because both act on the nitric oxide pathway (GTN as an organic nitrate, beetroot by a different route). This is additive rather than the dangerous amplified drop seen when nitrates are combined with erection medicines such as sildenafil. Keep your beetroot intake steady and tell your GP or cardiologist you take it.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does L-Citrulline interact with ?
Taking L-citrulline with glyceryl trinitrate (GTN) can add up their blood-pressure-lowering effects, so you may notice more dizziness, lightheadedness or a headache, particularly while a GTN spray or patch is working, because both raise nitric oxide (GTN as an organic nitrate, citrulline by feeding the arginine pathway). This is additive rather than the dangerous amplified drop seen when nitrates are combined with erection medicines such as sildenafil. Keep your citrulline dose steady and tell your GP or cardiologist you take it.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does NAC interact with ?
Taking NAC with glyceryl trinitrate (GTN) can make GTN act more strongly, which may mean a more pronounced headache and a larger drop in blood pressure than GTN alone, because NAC is a sulfur-rich compound and GTN needs sulfur groups in the body to work. If you use a GTN spray or patch and take NAC, watch for dizziness, faintness on standing, or worse headaches, and tell your GP or pharmacist so they can review the timing or doses.
Evidence: Supported by human study data.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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