Medication · nsaid

Supplements and Diclofenac diethyl.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Diclofenac diethyl, sold under the brand names Voltarol Emulgel, Voltarol Pain-eze Emulgel, is a non-steroidal anti-inflammatory drug (NSAID): it inhibits cyclooxygenase enzymes, with documented gastrointestinal and renal long-term risks.

Diclofenac diethyl is an NSAID, a non-steroidal anti-inflammatory drug. The class inhibits cyclooxygenase enzymes (COX-1 and COX-2 depending on selectivity), reducing pain and inflammation driven by prostaglandins. It also reduces the protective gastric and renal prostaglandin signalling that drives the side effect profile. Use at high doses or sustained over time carries gastric ulceration risk (mitigated when a PPI is given alongside), reduced antihypertensive effect of ACE inhibitors and ARBs, additive renal stress in CKD3+, and additive antiplatelet effect with aspirin or clopidogrel. The supplement surface divides into two patterns. Compounds that target the same pathway (curcumin, boswellia, omega-3 EPA at higher doses) overlap mechanism with NSAIDs in the COX cascade. Additive effects are real but rarely problematic at OTC doses. Ginkgo, garlic extract, and fish oil at high doses add to bleeding risk when stacked with NSAIDs, especially around dental work or surgery.

We have not yet completed an explicit assessment of supplement interactions with Diclofenac diethyl in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Diclofenac diethyl alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Your whole stack

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the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.