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Medication · hrt estrogen

Supplements and Combined ethinylestradiol 30mcg.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Combined ethinylestradiol 30mcg is hormone replacement therapy (oestrogen component) for menopausal symptoms.

Combined ethinylestradiol 30mcg is hormone replacement therapy (the oestrogen component). UK prescribing has shifted substantially since the early 2000s WHI trial retreat. Transdermal oestradiol is now the preferred delivery route over oral conjugated equine oestrogens, because the VTE and stroke risk signals were largely associated with the oral route. The supplement surface for the transdermal route is small, because the gut wall and first-pass liver metabolism are bypassed. Oral oestrogen formulations remain in CYP3A4 territory. St John's Wort is flagged by the BNF for potentially reduced efficacy. Symptom relief supplements often co-used during HRT (black cohosh, soya isoflavones, red clover, evening primrose oil) sit on top of HRT without strong interaction signals. The evidence base for any of them as additive benefit is modest. Vitamin D and calcium status matter for the bone density conversation.

We have not yet completed an explicit assessment of supplement interactions with Combined ethinylestradiol 30mcg in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Combined ethinylestradiol 30mcg alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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How we grade severity, choose what's in scope, and what we exclude.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.