Medication · arb

Supplements and Co-careldopa (Carbidopa/levodopa).

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Co-careldopa (Carbidopa/levodopa), sold under the brand names Sinemet, Caramet, Stalevo, Lecado, is an angiotensin II receptor blocker (ARB): it lowers blood pressure by blocking the angiotensin II receptor directly.

Co-careldopa (Carbidopa/levodopa) is an angiotensin II receptor blocker (ARB). The class blocks the angiotensin II type 1 receptor directly, achieving similar BP reduction to ACE inhibitors without the bradykinin cough side effect. Renal monitoring is the same as for ACE inhibitors. Annual U&E, with attention to potassium especially in CKD. Where supplements meet ARBs, the additive BP signal from nitrate pathway compounds (beetroot, hibiscus) matters. So does the additive potassium signal from supplements like liquorice, where the latter opposes BP control directly. NSAIDs blunt the antihypertensive effect of ARBs much as they do for ACE inhibitors. The CYP-mediated interactions vary across the class. Losartan is the most CYP-sensitive; candesartan and irbesartan less so. The supplement profile is therefore ARB-specific rather than uniform.

We have not yet completed an explicit assessment of supplement interactions with Co-careldopa (Carbidopa/levodopa) in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Co-careldopa (Carbidopa/levodopa) alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

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If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.