Medication · sglt2 inhibitor

Supplements and Canagliflozin.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Canagliflozin, sold under the brand name Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor: it lowers blood glucose by increasing urinary glucose excretion.

Canagliflozin is an SGLT2 inhibitor. The full name is sodium glucose cotransporter 2. The class lowers blood glucose by increasing urinary glucose excretion. It also carries a separate cardiovascular and renal benefit shown in DAPA-HF, EMPA-REG, and the CKD trials, leading to expanded indication in heart failure and CKD even without diabetes. The supplement surface is small because SGLT2 inhibitors are minimally CYP metabolised. The clinically important issues are urinary tract and genital fungal infections (since glucose in the urine creates favourable conditions), volume depletion in heat or illness (the diuretic effect adds to dehydration risk), and the rare diabetic ketoacidosis presentation including the unusual "euglycaemic" form. Cranberry supplementation often comes up for UTI prevention. The Cochrane evidence supports modest efficacy in recurrent UTI in women. Magnesium status warrants attention given the modest urinary magnesium loss that these inhibitors produce.

We have not yet completed an explicit assessment of supplement interactions with Canagliflozin in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Canagliflozin alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.