Supplements and Bisoprolol.
Bisoprolol, sold under the brand names Cardicor, Emcor, is a beta-blocker: it reduces heart rate and cardiac output by antagonising beta-adrenergic receptors.
Bisoprolol is a beta-blocker selective for the beta-1 receptor, and the most prescribed agent in this class in England. The drug slows heart rate. Uses are hypertension, stable angina, and at lower doses heart failure with reduced ejection fraction. The selectivity for beta-1 over beta-2 is relative, not absolute, so the asthma caution carries: bronchospasm risk rises as the dose climbs and the drug starts to touch airway receptors as well. Two cardiac interactions are worth flagging on the supplement side. The first is additive bradycardia, where CoQ10's effect is small and clinically minor while vagally active compounds matter more. The second is additive hypotension, where beetroot, hibiscus, and garlic stack on the BP side. Bisoprolol is not strongly CYP metabolised, so the CYP interactions are quieter than with statins or SSRIs. Watch in the early weeks for a resting heart rate below 50, or symptomatic dizziness on standing. Either warrants a GP review of dose rather than supplement adjustment.
Below are the 7 documented pairs we have explicitly assessed against Bisoprolol in the Distil database: 7 caution. The pairs cluster around 1 mechanism: Additive blood-pressure lowering. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 13 October 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive blood-pressure lowering
Caution Does Beetroot Extract interact with Bisoprolol?
Beetroot lowers blood pressure through the nitric oxide pathway, and bisoprolol lowers blood pressure through beta-1 receptor blockade. Used together, the combined blood-pressure effect is mild but real. Watch for dizziness on standing, especially in the first two weeks. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Caution Does Garlic Extract interact with Bisoprolol?
Garlic supplements may lower blood pressure a little, mostly when it is above target, and bisoprolol lowers it too, so together they may bring it down a bit further. If you feel dizzy or light-headed, especially when you stand up, check your blood pressure and tell your GP. Garlic's effect tends to build over several weeks, so keep an eye on your readings for the first three months or so.
Evidence: Limited human data, from small studies or case reports.
Caution Does Hibiscus Extract interact with Bisoprolol?
Hibiscus tends to lower blood pressure on its own, and bisoprolol is a beta blocker that lowers it too. Taken together the blood-pressure effects may stack, so watch for dizziness on standing, especially in the first couple of weeks. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Melatonin interact with Bisoprolol?
Taken at night, melatonin can modestly lower blood pressure during sleep. Combined with a blood-pressure medicine like bisoprolol this may add up to a slightly larger drop than the medicine alone. There is also a second point worth knowing: beta-blockers such as bisoprolol can suppress your own natural melatonin, so some people taking them sleep better when melatonin is added. Either way, if you notice dizziness, check your blood pressure and mention it to your prescriber.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Pine Bark Extract interact with Bisoprolol?
Pine bark extract (pycnogenol) mildly lowers blood pressure, and bisoprolol lowers it too. The combined effect is small but real. Watch for dizziness on standing in the first couple of weeks and tell your GP if it happens.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Spirulina interact with Bisoprolol?
Spirulina has a mild blood-pressure-lowering effect of its own, shown in human trials. Bisoprolol lowers blood pressure mainly by slowing the heart and easing its workload. Used together, the combined effect tends to be a little larger than the medicine alone. Watch for dizziness on standing in the first couple of weeks, and tell your GP if it happens so your dose can be reviewed.
Evidence: Limited human data, from small studies or case reports.
Caution Does Taurine interact with Bisoprolol?
Taurine tends to lower blood pressure a little on its own and may lower heart rate slightly, and bisoprolol is a beta blocker that lowers both. Taken together the effects may stack, so watch for dizziness on standing or feeling unusually tired, especially in the first couple of weeks. Taurine's own effect on blood pressure is small. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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