Medication · dpp4 inhibitor

Supplements and Alogliptin.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Alogliptin, sold under the brand names Vipidia, Vipdomet, is a dipeptidyl peptidase-4 (DPP-4) inhibitor: it prolongs the action of incretin hormones.

Alogliptin is a DPP-4 inhibitor (dipeptidyl peptidase-4). Use is Type 2 diabetes as a second or third line oral agent. The class prolongs the action of endogenous incretin hormones (GLP-1 and GIP) by blocking their degradation, which raises insulin release in a way tied to glucose with low hypoglycaemia risk. UK prescribing centres on sitagliptin, linagliptin, alogliptin, and saxagliptin. The supplement surface is small because DPP-4 inhibitors have minimal CYP metabolism. Linagliptin is the cleanest in this respect. Clinical issues here are mostly glycaemic and additive. Berberine, cinnamon at extract doses, alpha lipoic acid, and chromium at high doses all carry small additive HbA1c effects. The stack rarely causes hypoglycaemia, but it is worth tracking in patients on tight glycaemic targets. Acute pancreatitis is a rare adverse effect flagged for the class.

We have not yet completed an explicit assessment of supplement interactions with Alogliptin in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Alogliptin alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.