Medication · antidepressant other

Supplements and Agomelatine.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Agomelatine, sold under the brand name Valdoxan, is an antidepressant: depending on the agent, it acts on serotonin, noradrenaline, or both.

Agomelatine sits in the BNF "other antidepressants" group. The group includes the SNRIs (venlafaxine, duloxetine), the atypicals (mirtazapine, agomelatine, vortioxetine), and the older tetracyclics. The clinical class matters more than the BNF group, because the supplement profile differs sharply across it. SNRIs share the SSRI serotonergic concerns. Mirtazapine sits closer to the sedating, appetite-stimulating profile. Agomelatine is heavily liver-metabolised with mandatory LFT monitoring. Where these antidepressants share a supplement surface, it is St John's Wort (hard exclude across the class), 5-HTP (hard exclude on serotonergic grounds), rhodiola, and any supplement with significant sedating or activating effect depending on the agent. Discontinuation profiles differ too. Venlafaxine has the heaviest withdrawal syndrome of common antidepressants. Agomelatine probably the lightest.

Below are the 1 documented pair we have explicitly assessed against Agomelatine in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Additive CNS sedation. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 15 June 2026. Each interaction below is assessed against PubMed-indexed evidence.

Additive CNS sedation

Amber Does Melatonin interact with ?

Agomelatine is a prescription antidepressant that acts on the same melatonin receptors as a melatonin supplement, so taking melatonin on top may add to the sleep-promoting effect. There is no direct study of the two together, so this is a cautionary note rather than a firm rule. Agomelatine also needs liver-function monitoring, which is a separate reason to keep your prescriber informed of anything you add.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

BNF: Agomelatine · BNF: Melatonin

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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