Class landing · HRT

Supplements and HRT.

Oestrogen, progesterone and the supplements that complement or compete with hormone replacement.

HRT (oestrogen with or without progesterone) is the most common pharmacological intervention for menopause symptoms. Supplement questions tend to come up in three directions: phytoestrogen overlap, CYP3A4 interaction, and bone-health stacking.

St John’s Wort is the clearest exclusion: it accelerates oestrogen and tibolone clearance via CYP3A4 induction, which can reduce HRT effect and return menopausal symptoms despite a prescribed dose. Phytoestrogens (soy isoflavones, red clover) do not interact with HRT in any documented sense, but the rationale for adding them while already on HRT is rarely strong. Vitamin D + K2 + magnesium stacking on HRT for bone density is well-supported. The class page above pre-selects oestradiol, micronised progesterone and tibolone; add the supplements you take and check.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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Add all the supplements and medications you take, then check them together in one go.

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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

Severe
Caution
No known interaction
Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology

The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.