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Class landing · HRT

Supplements and HRT.

Oestrogen, progesterone and the supplements that complement or compete with hormone replacement.

HRT (oestrogen with or without progesterone) is the most common pharmacological intervention for menopause symptoms. Supplement questions tend to come up in three directions: phytoestrogen overlap, CYP3A4 interaction, and bone-health stacking.

St John’s Wort is the clearest exclusion: it accelerates oestrogen and tibolone clearance via CYP3A4 induction, which can reduce HRT effect and return menopausal symptoms despite a prescribed dose. Phytoestrogens (soy isoflavones, red clover) do not interact with HRT in any documented sense, but the rationale for adding them while already on HRT is rarely strong. Vitamin D + K2 + magnesium stacking on HRT for bone density is well-supported. The class page above pre-selects oestradiol, micronised progesterone and tibolone; add the supplements you take and check.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
Type the supplement name. Click each match to add it.
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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Your whole stack

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  • the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
  • where your current routine may be leaving you short of your goals
  • the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.