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Class landing · HRT

Supplements and HRT.

Oestrogen, progesterone and the supplements that complement or compete with hormone replacement.

HRT (oestrogen with or without progesterone) is the most common pharmacological intervention for menopause symptoms. Supplement questions tend to come up in three directions: phytoestrogen overlap, CYP3A4 interaction, and bone-health stacking.

St John’s Wort is the clearest exclusion: it accelerates oestrogen and tibolone clearance via CYP3A4 induction, which can reduce HRT effect and return menopausal symptoms despite a prescribed dose. Phytoestrogens (soy isoflavones, red clover) do not interact with HRT in any documented sense, but the rationale for adding them while already on HRT is rarely strong. Vitamin D + K2 + magnesium stacking on HRT for bone density is well-supported. The class page above pre-selects oestradiol, micronised progesterone and tibolone; add the supplements you take and check.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
Type the supplement name. Click each match to add it.
Brand or generic name works. Click each match to add it.

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If a supplement or medication you take isn't in our autocomplete, tell us and we'll add it in the next quarterly update.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history.