Class landing · GLP-1 agonists

Supplements and GLP-1 agonists.

Semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro) and the supplement questions that matter at reduced food intake.

GLP-1 agonists (semaglutide, liraglutide, tirzepatide) slow gastric emptying and reduce appetite. The interaction surface is not classical pharmacology so much as logistics: at substantially lower food intake, micronutrient adequacy stops being automatic.

The supplement questions worth asking on a GLP-1 are mostly about coverage: protein adequacy first (whey or pea protein at 25 to 40 g per day is a reasonable floor for muscle preservation), then a multivitamin for general micronutrient cover, then magnesium if cramps or sleep change. Slower gastric emptying may push timing of mineral supplements toward later in the day. We are still expanding direct GLP-1 interaction coverage; tell us what you take and we will check.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.