Class landing · GLP-1 agonists

Supplements and GLP-1 agonists.

Semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro) and the supplement questions that matter at reduced food intake.

GLP-1 agonists (semaglutide, liraglutide, tirzepatide) slow gastric emptying and reduce appetite. The interaction surface is not classical pharmacology so much as logistics: at substantially lower food intake, micronutrient adequacy stops being automatic.

The supplement questions worth asking on a GLP-1 are mostly about coverage: protein adequacy first (whey or pea protein at 25 to 40 g per day is a reasonable floor for muscle preservation), then a multivitamin for general micronutrient cover, then magnesium if cramps or sleep change. Slower gastric emptying may push timing of mineral supplements toward later in the day. We are still expanding direct GLP-1 interaction coverage; tell us what you take and we will check.

Database last updated 2026-11-13. Free for everyone. No account, no paywall. · Browse coverage A-Z

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

Severe
Caution
No known interaction
Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology

The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.