Class landing · GLP-1 agonists

Supplements and GLP-1 agonists.

Semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro) and the supplement questions that matter at reduced food intake.

GLP-1 agonists (semaglutide, liraglutide, tirzepatide) slow gastric emptying and reduce appetite. The interaction surface is not classical pharmacology so much as logistics: at substantially lower food intake, micronutrient adequacy stops being automatic.

The supplement questions worth asking on a GLP-1 are mostly about coverage: protein adequacy first (whey or pea protein at 25 to 40 g per day is a reasonable floor for muscle preservation), then a multivitamin for general micronutrient cover, then magnesium if cramps or sleep change. Slower gastric emptying may push timing of mineral supplements toward later in the day. We are still expanding direct GLP-1 interaction coverage; tell us what you take and we will check.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.