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Supplements and diuretics.

The mineral-depletion and potassium story alongside furosemide, bendroflumethiazide and spironolactone.

Diuretics change the body’s mineral balance, and that is where supplements meet them. Loop diuretics (furosemide) and thiazides (bendroflumethiazide) increase the loss of magnesium, potassium and zinc in the urine, so replacing these can be sensible, but it should be tracked with blood tests rather than guessed. Thiazides do the opposite with calcium, holding onto it, so calcium and high-dose vitamin D can push blood calcium too high.

The one to take seriously is potassium with a potassium-sparing diuretic (spironolactone, eplerenone, amiloride): together they can raise blood potassium to a dangerous level, so this is a combination to avoid without monitoring. Blood-pressure-lowering supplements (beetroot, hibiscus, taurine) can also stack on top of a diuretic’s effect, and lithium levels rise with thiazides. Most of this is manageable with the right blood tests; we flag the ones that are not.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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