Class landing · Diuretics

Supplements and diuretics.

The mineral-depletion and potassium story alongside furosemide, bendroflumethiazide and spironolactone.

Diuretics change the body’s mineral balance, and that is where supplements meet them. Loop diuretics (furosemide) and thiazides (bendroflumethiazide) increase the loss of magnesium, potassium and zinc in the urine, so replacing these can be sensible, but it should be tracked with blood tests rather than guessed. Thiazides do the opposite with calcium, holding onto it, so calcium and high-dose vitamin D can push blood calcium too high.

The one to take seriously is potassium with a potassium-sparing diuretic (spironolactone, eplerenone, amiloride): together they can raise blood potassium to a dangerous level, so this is a combination to avoid without monitoring. Blood-pressure-lowering supplements (beetroot, hibiscus, taurine) can also stack on top of a diuretic’s effect, and lithium levels rise with thiazides. Most of this is manageable with the right blood tests; we flag the ones that are not.

Loading database stats…

For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

Add every supplement you take. Type a name and click each match to add it, as many as you like.

Your medications

Add all your medications, brand or generic. Type and click each match to add it.

Anything we should know? (optional)

Pick any that apply. We adjust the findings where context changes the answer.

I confirm I am 18 or over. This tool gives evidence-graded information, not medical advice; always discuss changes with your GP or pharmacist.

Add all the supplements and medications you take, then check them together in one go.

Not sure where to start? Try one:

How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

Want this checked across everything you take?

This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

See a real sample report

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.