Most of the energy supplements on the shelf will not do much, and the ones that genuinely help usually help because you were short of something specific. So the most useful "energy supplement" is often a blood test that tells you what is actually low. Tiredness that responds to a supplement is, more often than not, iron or B12.
Iron: the first thing to rule out
Low iron is one of the most common causes of genuine fatigue, particularly in women who menstruate, and it can drag energy down long before it shows up as anaemia on a standard blood count. The marker to ask for is ferritin. If it is low, correcting it can make a real difference, and if it is fine, iron will do nothing and is not worth taking. This is the clearest case for a test before supplementing.
B12: the other one worth checking
Low B12 causes fatigue, brain fog and sometimes tingling, and it is more likely if you eat little or no animal food or take a long-term acid-reducer or metformin. A B-complex only helps if you were genuinely low; topping up normal levels does not create extra energy.
The ones with weaker cases
CoQ10 is widely sold for energy, but the general evidence for it in healthy people is thin. It has a clearer rationale for people on statins, which depletes it, than as a blanket energy supplement. The various "energy" blends built around high-dose B vitamins mostly produce expensive urine if your levels were already normal.
The honest version
If you are tired, the highest-value move is not a supplement aisle but a blood test for iron and B12, and an honest look at sleep, stress and caffeine timing. Supplements fix a shortfall; they do not manufacture energy out of nothing. To check any energy supplement against a medication you take, the free checker will show you the result and the reasoning.