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Class landing · NSAIDs

Supplements and NSAIDs.

Ibuprofen, naproxen, diclofenac and the supplement-related GI and renal considerations.

NSAIDs (ibuprofen, naproxen, diclofenac and others) are the most-used over-the-counter analgesics. They carry two long-term risks worth pairing against supplement choices: gastrointestinal (ulcer, bleeding) and renal (reduced kidney function with chronic use).

The supplement pairs that add to NSAID bleeding risk are ginkgo biloba, high-dose garlic extract, and high-dose omega-3 (above 3g combined EPA + DHA per day): the additive antiplatelet effect is mild at short-course standard NSAID use but climbs with chronic NSAID exposure or pre-surgery. Curcumin at high doses sits in the same category. The standard surgical rule is to stop these supplements at least one to two weeks before any planned procedure.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history.