Class landing · NSAIDs

Supplements and NSAIDs.

Ibuprofen, naproxen, diclofenac and the supplement-related GI and renal considerations.

NSAIDs (ibuprofen, naproxen, diclofenac and others) are the most-used over-the-counter analgesics. They carry two long-term risks worth pairing against supplement choices: gastrointestinal (ulcer, bleeding) and renal (reduced kidney function with chronic use).

The supplement pairs that add to NSAID bleeding risk are ginkgo biloba, high-dose garlic extract, and high-dose omega-3 (above 3g combined EPA + DHA per day): the additive antiplatelet effect is mild at short-course standard NSAID use but climbs with chronic NSAID exposure or pre-surgery. Curcumin at high doses sits in the same category. The standard surgical rule is to stop these supplements at least one to two weeks before any planned procedure.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Your whole stack

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the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.