Class landing · NSAIDs

Supplements and NSAIDs.

Ibuprofen, naproxen, diclofenac and the supplement-related GI and renal considerations.

NSAIDs (ibuprofen, naproxen, diclofenac and others) are the most-used over-the-counter analgesics. They carry two long-term risks worth pairing against supplement choices: gastrointestinal (ulcer, bleeding) and renal (reduced kidney function with chronic use).

The supplement pairs that add to NSAID bleeding risk are ginkgo biloba, high-dose garlic extract, and high-dose omega-3 (above 3g combined EPA + DHA per day): the additive antiplatelet effect is mild at short-course standard NSAID use but climbs with chronic NSAID exposure or pre-surgery. Curcumin at high doses sits in the same category. The standard surgical rule is to stop these supplements at least one to two weeks before any planned procedure.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.