Supplements and Rosuvastatin calcium.
Rosuvastatin calcium, sold under the brand names Crestor, Ezallor Sprinkle, is a statin: it lowers LDL cholesterol by inhibiting HMG-CoA reductase. Statins are the most-prescribed class in the UK.
Rosuvastatin is the most potent statin per milligram, and the one with the lowest CYP3A4 dependence. It is primarily excreted unchanged via the kidneys and biliary tract, with only minor CYP2C9 involvement. That means the CYP3A4 supplement interactions that hit simvastatin (and to a lesser extent atorvastatin) barely apply here. Rosuvastatin is the statin of choice when a patient needs strong LDL reduction with minimal drug interaction concern. It is often the switch destination from simvastatin in older patients on polypharmacy. Two supplement interactions matter. Additive lipid lowering (berberine, plant sterols, red yeast rice carry small additive effects). And additive myopathy risk with niacin at high doses. Rosuvastatin shows a slightly higher diabetes incidence signal in long observational data than other statins. CARDS and JUPITER are the relevant evidence base. The standard clinical move with new statin myalgia is dose reduction, switch, or check vitamin D, which has a small reproducible effect on statin-tolerability data.
Below are the 5 documented pairs we have explicitly assessed against Rosuvastatin calcium in the Distil database: 3 caution and 2 good to know. The pairs cluster around 4 mechanisms: Additive lipid lowering, Additive HMG-CoA reductase inhibition, OATP transporter inhibition (reduced absorption), and Statin-induced CoQ10 depletion. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 12 October 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive lipid lowering
Caution Does Berberine interact with Rosuvastatin calcium?
Berberine may lower LDL cholesterol on its own, so adding it to rosuvastatin may push your cholesterol lower than the statin alone; if you take both, ask your GP for a lipid panel sooner than usual. Berberine is not known to change rosuvastatin levels in the blood, so the point to watch is the combined effect on your cholesterol rather than a rise in statin side effects.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Good to know Does Beta-Glucan interact with Rosuvastatin calcium?
Oat beta-glucan lowers LDL cholesterol by trapping bile acids in the gut, a different route from how a statin works. Taking the two together is complementary, not a harmful clash, and the small extra cholesterol reduction is a benefit. We treat this pair as safe to combine.
Evidence: Supported by human study data.
Additive HMG-CoA reductase inhibition
Caution Does Bergamot Extract (BPF / Bergavit40) interact with Rosuvastatin calcium?
Bergamot's active flavonoids lower LDL cholesterol through the same liver pathway rosuvastatin acts on, so combining them adds to the cholesterol-lowering effect. A clinical trial showed bergamot added to rosuvastatin lowered LDL more than rosuvastatin alone. This can be intentional under medical supervision, but tell your GP before combining so your dose and cholesterol levels can be reviewed together rather than the two effects stacking unplanned.
Evidence: Supported by human study data.
OATP transporter inhibition (reduced absorption)
Caution Does Green Tea Extract interact with Rosuvastatin calcium?
Green tea extract can lower the amount of rosuvastatin in your bloodstream by interfering with the transporter that moves the drug into cells. In a study of healthy volunteers, a concentrated green tea extract reduced rosuvastatin levels by about a fifth. It is not certain whether this changes how well rosuvastatin lowers cholesterol, so the sensible approach is to keep your green tea extract intake steady and let your prescriber know you take it, especially around a cholesterol check.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Statin-induced CoQ10 depletion
Good to know Does Coenzyme Q10 interact with Rosuvastatin calcium?
Statins do reduce plasma CoQ10 levels, but replacing it does not reliably ease muscle aches: four analyses of the trials split two against two, the two that measured muscle-damage enzymes found no change, and CoQ10 does not help people stay on their statin. We treat the pair as safe to combine, and it may be worth a trial if you already have statin muscle aches. If you have no symptoms, the evidence does not support taking it routinely.
Evidence: Well established across multiple human studies or interaction references.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 until 30 June 2027 · £79 from 1 July 2027.
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