Medication · ppi

Supplements and Lansoprazole.

Every documented pair, every citation. Below: 2 documented pairs grouped by mechanism.

Lansoprazole, sold under the brand names Zoton, Prevacid, is a proton pump inhibitor (PPI): it suppresses gastric acid production by inhibiting the H+/K+ ATPase pump.

Below are the 2 documented pairs we have explicitly assessed against Lansoprazole in the Distil database: 2 amber. The pairs cluster around 1 mechanism: Absorption interference. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Absorption interference

Amber Magnesium Glycinate

Long-term lansoprazole use is associated with low blood magnesium in about 1 in 5 chronic users. Supplementing magnesium is generally helpful, but if you have heart, kidney, or muscle symptoms on long-term lansoprazole, ask your GP for a magnesium blood test.

PMID 25394217 · BNF: Lansoprazole

Amber Vitamin B12

Long-term lansoprazole use reduces stomach acid and slows how well your body absorbs vitamin B12 from food. After about two years of daily use, B12 deficiency becomes notably more likely. If you take lansoprazole long term, ask your GP about an annual B12 blood test.

PMID 24327038 · BNF: Lansoprazole

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Anything we should know? (optional)

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Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us and we'll add it in the next quarterly update.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a comprehensive personalised stack reasoned against this same database, the Distil report is the next step up.