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Class landing · Benzodiazepines

Supplements and benzodiazepines.

Diazepam, lorazepam, temazepam and the supplements that add CNS sedation.

Benzodiazepines (diazepam, lorazepam, temazepam) potentiate GABA at the GABA-A receptor. Several supplements act on the same axis. Combining them adds sedation in a way that is sometimes useful and often overshoots.

Kava is the clearest exclusion: independent hepatotoxicity risk (the UK MHRA suspended kava-containing medicines for human consumption in 2003) plus additive GABAergic sedation. Valerian and passionflower add CNS depression in a softer, dose-dependent way; the Akhondzadeh 2001 RCT found passionflower clinically comparable to oxazepam for generalised anxiety, which gives you a sense of the additive potential. Ashwagandha is theoretical-only at this stage but worth flagging. Note that St John’s Wort reduces diazepam levels (CYP3A4) but does not affect lorazepam or temazepam, which are glucuronidated rather than CYP3A4-metabolised. The class page pre-selects all three benzodiazepines.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history.